AI-guided exploration of viral shells

Our MitoVir lab at the University of Groningen has received an NWO Open Competition Domain Science XS grant for the project “AI-guided exploration of viral capsid interfaces as antiviral targets.” [Link]

Viruses are tiny infectious particles that protect their genetic material inside a shell, similar to how an egg protects what is inside. This shell is essential for the virus to enter cells and spread. Many antivirals work by blocking virus multiplication in cells, but these can lose effectiveness and may cause side effects.

In this one‑year project, we explore a different idea: targeting the virus’ shell itself. Using artificial intelligence, we will search for weak spots in this shell in human adenovirus and design molecules that disrupt it. This research aims to open new routes toward medicines that prevent viral infections.